Acetaminophen Pathway (toxic doses), Pharmacokinetics N Acetyl 4 benzoquinone imine (NAPQI, N Acetyl p benzoquinonimine, CAS Number: 50700 49 7) Cayman Chemical GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Full article: The acetaminophen metabolite N acetyl p benzoquinone imine ( NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5 oxoprolinuric acidosis?
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