Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol's Impact on Glutathione and Liver Damage Top 7 FAQs On Liposomal Glutathione vs. Traditional Glutathione West Bengal Chemical Industries Limited TYLENOL [Acetaminophen APAP]why it may cause harm Tylenol should likely be avoided in excess by genetically vulnerable children. GENETICALLY VULNERABLE likely meanschildren with limited supplies of GLUTATHIONE. The problem with TYLENOL