Identification, characterization, and structure activity relationship of the ASIC3 selective peptide WRPRFa Communications Chemistry Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a Tolerance and Tachyphylaxis Drug Tolerance Drug Tachyphylaxis Pharmacology Made Easy 2021A12 Define the terms tolerance and tachyphylaxis. Discuss the different mechanisms by which tolerance can develop, giving examples where appropriate.