Paracetamol toxicity Deranged Physiology Frontiers Potential adverse actions of prenatal exposure of acetaminophen to offspring Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.