How glutathione acts to protect mammalian organisms from potentially toxic exogenous and endogenous compounds Ivory Research GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione, Pollution, and Your Health Body In Balance