Full article: The central role of glutathione in the pathophysiology of human diseases Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes Glutathione (GSH), the body's primary intracellular antioxidant, plays a fundamental role in maintaining redox balance and detoxification. In normal physiology, this is protective. However, in oncology, the picture becomes more nuanced. Emerging