Stimulation of the Herpes Simplex Virus Type I Protease by Antichaeotrophic Salts () HERPES VIRUSES reactivation Sequence of events** When a person is suffering from chronic stress, excess Cortisol and Adrenaline with lowered Glutathione. Glutathione is the body's most important antioxidant. Insufficient Glutathione reduces the Cold sore triggers vary from person to person, but HSV is an opportunistic infection. That means it rears its ugly head when, for whatever reason, your immune system is too weak to TNF inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway Scientific Reports