How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Before vs. after 3 months of GHK Cu peptide therapy smoother texture, more even tone, and skin that looks healthier overall. Small peptide, big difference Synergy of GHKCu and hyaluronic acid on collagen IV upregulation via fibroblast and exvivo skin tests Jiang 2023 Journal of Cosmetic Dermatology Wiley Online Library A) Serum levels of growth hormone (GH) and (B) insulin like growth Download Scientific Diagram