Acetaminophen Toxicity in Children: Diagnosis, Clinical Assessment, and Treatment of Acute Overingestion Consultant360 Can Tylenol (acetaminophen) deplete glutathione levels in the body? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Nini Munoz , PhD. Since the administration claimed Tylenol as a cause of autism, we've seen a number of alternative and 'integrative' practitioners talking Instagram